Advancing genomic research depends on the accessing and sharing of genomic data. However, the increasing need for sharing escalates the tension between genomic privacy and openness.
Promoting openness while protecting privacy is a challenge that cannot be overcome only with technical solutions such as encryption and differential privacy. Although such solutions are crucial, we still need to confront some fundamental normative tensions that are intensified in the era of genomics and big data. Here are at least three:
The right to genomic privacy is not an absolute right. If privacy is understood as control over information or data, privacy is not about maximal levels of control, but rather about reasonable measures of control.
Although individual control is necessary, it is not a sufficient safeguard of privacy. Individuals’ willingness to be open about their data does not obviate responsibility for reducing privacy risks on the part of the data users.
Data governance models, such as data cooperatives, that enable meaningful and continuous roles of the individuals whose data are at stake hold promise for reconciling privacy and openness.
This is a graduate textbook of advanced tutorials on the theory of cryptography and computational complexity. In particular, the chapters explain aspects of garbled circuits, public-key cryptography, pseudorandom functions, one-way functions, homomorphic encryption, the simulation proof technique, and the complexity of differential privacy. Most chapters progress methodically through motivations, foundations, definitions, major results, issues surrounding feasibility, surveys of recent developments, and suggestions for further study.
This book honors Professor Oded Goldreich, a pioneering scientist, educator, and mentor. Oded was instrumental in laying down the foundations of cryptography, and he inspired the contributing authors, Benny Applebaum, Boaz Barak, Andrej Bogdanov, Iftach Haitner, Shai Halevi, Yehuda Lindell, Alon Rosen, and Salil Vadhan, themselves leading researchers on the theory of cryptography and computational complexity. The book is appropriate for graduate tutorials and seminars, and for self-study by experienced researchers, assuming prior knowledge of the theory of cryptography.
Hypothesis testing is a useful statistical tool in determining whether a given model should be rejected based on a sample from the population. Sample data may contain sensitive information about individuals, such as medical information. Thus it is important to design statistical tests that guarantee the privacy of subjects in the data. In this work, we study hypothesis testing subject to differential privacy, specifically chi-squared tests for goodness of fit for multinomial data and independence between two categorical variables. We propose new tests for goodness of fit and independence testing that like the classical versions can be used to determine whether a given model should be rejected or not, and that additionally can ensure differential privacy. We give both Monte Carlo based hypothesis tests as well as hypothesis tests that more closely follow the classical chi-squared goodness of fit test and the Pearson chi-squared test for independence. Crucially, our tests account for the distribution of the noise that is injected to ensure privacy in determining significance. We show that these tests can be used to achieve desired significance levels, in sharp contrast to direct applications of classical tests to differentially private contingency tables which can result in wildly varying significance levels. Moreover, we study the statistical power of these tests. We empirically show that to achieve the same level of power as the classical non-private tests our new tests need only a relatively modest increase in sample size.
merging large-scale data sources hold tremendous potential for new scientific research into human biology, behaviors, and relationships. At the same time, big data research presents privacy and ethical challenges that the current regulatory framework is ill-suited to address. In light of the immense value of large-scale research data, the central question moving forward is not whether such data should be made available for research, but rather how the benefits can be captured in a way that respects fundamental principles of ethics and privacy.
In response, this Essay outlines elements of a new ethical framework for big data research. It argues that oversight should aim to provide universal coverage of human subjects research, regardless of funding source, across all stages of the information lifecycle. New definitions and standards should be developed based on a modern understanding of privacy science and the expectations of research subjects. In addition, researchers and review boards should be encouraged to incorporate systematic risk-benefit assessments and new procedural and technological solutions from the wide range of interventions that are available. Finally, oversight mechanisms and the safeguards implemented should be tailored to the intended uses, benefits, threats, harms, and vulnerabilities associated with a specific research activity.
Development of a new ethical framework with these elements should be the product of a dynamic multistakeholder process that is designed to capture the latest scientific understanding of privacy, analytical methods, available safeguards, community and social norms, and best practices for research ethics as they evolve over time. Such a framework would support big data utilization and help harness the value of big data in a sustainable and trust-building manner.
The β-model of random graphs is an exponential family model with the degree sequence as a sufficient statistic. In this paper, we contribute three key results. First, we characterize conditions that lead to a quadratic time algorithm to check for the existence of MLE of the β-model, and show that the MLE never exists for the degree partition β-model. Second, motivated by privacy problems with network data, we derive a differentially private estimator of the parameters of β-model, and show it is consistent and asymptotically normally distributed - it achieves the same rate of convergence as the nonprivate estimator. We present an efficient algorithm for the private estimator that can be used to release synthetic graphs. Our techniques can also be used to release degree distributions and degree partitions accurately and privately, and to perform inference from noisy degrees arising from contexts other than privacy. We evaluate the proposed estimator on real graphs and compare it with a current algorithm for releasing degree distributions and find that it does significantly better. Finally, our paper addresses shortcomings of current approaches to a fundamental problem of how to perform valid statistical inference from data released by privacy mechanisms, and lays a foundational groundwork on how to achieve optimal and private statistical inference in a principled manner by modeling the privacy mechanism; these principles should be applicable to a class of models beyond the β-model.
We present a new algorithm for locating a small cluster of points with differential privacy [Dwork, McSherry, Nissim,and Smith, 2006]. Our algorithm has implications to private data exploration, clustering, and removal of outliers. Furthermore, we use it to significantly relax the requirements of the sample and aggregate technique [Nissim, Raskhodnikova,and Smith, 2007], which allows compiling of "off the shelf" (non-private) analyses into analyses that preserve differential privacy.
An order-revealing encryption scheme gives a public procedure by which two ciphertexts can be compared to reveal the ordering of their underlying plaintexts. We show how to use order-revealing encryption to separate computationally efficient PAC learning from efficient (ϵ,δ)-differentially private PAC learning. That is, we construct a concept class that is efficiently PAC learnable, but for which every efficient learner fails to be differentially private. This answers a question of Kasiviswanathan et al. (FOCS '08, SIAM J. Comput. '11). To prove our result, we give a generic transformation from an order-revealing encryption scheme into one with strongly correct comparison, which enables the consistent comparison of ciphertexts that are not obtained as the valid encryption of any message. We believe this construction may be of independent interest.
Increasingly, governments and businesses are collecting, analyzing, and sharing detailed information about individuals over long periods of time. Vast quantities of data from new sources and novel methods for large-scale data analysis promise to yield deeper understanding of human characteristics, behavior, and relationships and advance the state of science, public policy, and innovation. At the same time, the collection and use of fine-grained personal data over time is associated with significant risks to individuals, groups, and society at large. In this article, we examine a range of longterm data collections, conducted by researchers in social science, in order to identify the characteristics of these programs that drive their unique sets of risks and benefits. We also examine the practices that have been established by social scientists to protect the privacy of data subjects in light of the challenges presented in long-term studies. We argue that many uses of big data, across academic, government, and industry settings, have characteristics similar to those of traditional long-term research studies. In this article, we discuss the lessons that can be learned from longstanding data management practices in research and potentially applied in the context of newly emerging data sources and uses.
In this paper we initiate the study of adaptive composition in differential privacy when the length of the composition, and the privacy parameters themselves can be chosen adaptively, as a function of the outcome of previously run analyses. This case is much more delicate than the setting covered by existing composition theorems, in which the algorithms themselves can be chosen adaptively, but the privacy parameters must be fixed up front. Indeed, it isn't even clear how to define differential privacy in the adaptive parameter setting. We proceed by defining two objects which cover the two main use cases of composition theorems. A privacy filter is a stopping time rule that allows an analyst to halt a computation before his pre-specified privacy budget is exceeded. A privacy odometer allows the analyst to track realized privacy loss as he goes, without needing to pre-specify a privacy budget. We show that unlike the case in which privacy parameters are fixed, in the adaptive parameter setting, these two use cases are distinct. We show that there exist privacy filters with bounds comparable (up to constants) with existing privacy composition theorems. We also give a privacy odometer that nearly matches non-adaptive private composition theorems, but is sometimes worse by a small asymptotic factor. Moreover, we show that this is inherent, and that any valid privacy odometer in the adaptive parameter setting must lose this factor, which shows a formal separation between the filter and odometer use-cases.
Differential privacy is a mathematical definition of privacy for statistical data analysis. It guarantees that any (possibly adversarial) data analyst is unable to learn too much information that is specific to an individual. Mironov et al. (CRYPTO 2009) proposed several computational relaxations of differential privacy (CDP), which relax this guarantee to hold only against computationally bounded adversaries. Their work and subsequent work showed that CDP can yield substantial accuracy improvements in various multiparty privacy problems. However, these works left open whether such improvements are possible in the traditional client-server model of data analysis. In fact, Groce, Katz and Yerukhimovich (TCC 2011) showed that, in this setting, it is impossible to take advantage of CDP for many natural statistical tasks. Our main result shows that, assuming the existence of sub-exponentially secure one-way functions and 2-message witness indistinguishable proofs (zaps) for NP, that there is in fact a computational task in the client-server model that can be efficiently performed with CDP, but is infeasible to perform with information-theoretic differential privacy.
This article summarizes research exploring various models by which governments release data to the public and the interventions in place to protect the privacy of individuals in the data. Applying concepts from the recent scientific and legal literature on privacy, the authors propose a framework for a modern privacy analysis and illustrate how governments can use the framework to select appropriate privacy controls that are calibrated to the specific benefits and risks in individual data releases.